PDEs as drug targets
PDE4NPD and the EU
CDD News: GSK’s Kinetoplastid Research Data Set Available FREE Within CDD Vault
1 July 2016
In an effort to fuel open-source research and drug discovery in Kinetoplastid diseases, GSK Tres Cantos and CDD have assembled three Kineto Boxes containing 592 New Small Molecules.
Puts 65 million people at risk of infection, with 20,000 new cases annually. Affects the central nervous system, and also inflicts economic damage via infections in cattle.
A parasitic sporadic/epidemic disease infecting more than 12 million people worldwide, causing 20-30,000 deaths each year.
Causes cardiac disorders or digestive alterations in 40% of patients, and can lead to death (7,000 each year) or life-long disability. Chronically infects 6-7 million people.
Affects 78 countries, with 240 million infected people – imposing an economic burden second only to malaria in endemic countries.