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PDEs as drug targets

Phosphodiesterases make good drug targets because they bind small ligands and share similar catalytic mechanisms, while displaying unique architectures around their active sites. This allows for the development of selective inhibitors.

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PDE4NPD and the EU

The PDE4NPD Project is one of four neglected parasitic disease (NPD) projects funded under the auspices of the European Commission’s FP7 HEALTH programme.

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PDE4NPD delivers valuable drug discovery platform for neglected parasitic diseases

The four-year PDE4NPD (PhosphoDiEsterases for Neglected Parasitic Diseaseas) project will formally end this week. “I am happy to conclude that we have delivered promising lead candidates and a valuable drug discovery platform for neglected parasitic diseases,” said Principal Investigator Rob Leurs (VU Amsterdam).

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