Neglected parasitic diseases

Jointly fighting neglected diseases

Worldwide, more than 1.4 billion people suffer from a neglected parasitic disease (NPD), with consequences that can include blindness, disfigurement, long-term disability or death. 

Safe and effective treatments remain unavailable for most NPDs, and the PDE4NPD consortium has been established to discover novel treatments. 

The PDE4NPD drug discovery platform specifically targets parasitic phosphodiesterases (PDEs), aiming to find and develop selective inhibitors. The consortium focuses on three protozoan diseases and one major helminth disease: 

  • Human African trypanosomiasis (also known as sleeping sickness)
  • Leishmaniasis  
  • Chagas disease
  • Schistosomiasis (also known as Bilharzia or snail fever)

To ensure optimal exploitation of the data generated, there is a strong emphasis on developing an open innovation model for data sharing.